Hao Sun, Ph.D.

Hao Sun's Headshot
Assistant Professor
Chemistry Graduate Program Coordinator

Department of Chemistry and Chemical & Biomedical Engineering
Tagliatela College of Engineering
Education

Postdoctoral Fellow, Polymer Chemistry, Northwestern University
Ph.D., Organic Chemistry, University of Florida
M.Sc., Polymer Chemistry & Physics, Sun Yat-sen University
B.Sc., Chemistry, Wuhan University

About Hao

Hao is an organic and polymer chemist. He joined the faculty of the University of New Haven in August 2021. He will teach Organic Chemistry (CHEM2201) and Advanced Organic Chemistry (CHEM4501) in the fall of 2021.

HaoӰԭs research program seeks chemistry-centered multidisciplinary approaches to addressing the challenges in global health and environment. Several areas in the intersection of synthetic polymer chemistry, materials, and biomedicine will be investigated, with particular focus on those most closely related to environmental and biomedical applications. His current research interests are centered in: (1) developing chemically-recyclable polymer materials for environmental applications; (2) developing modular and scalable approach for polymer-based delivery systems of therapeutics (e.g., gene, peptides, and proteins); (3) designing next-generation sequence-defined polymers for understanding the role of monomer sequence in governing the material properties.

Professor SunӰԭs research group website:

Publications

Ӱԭ denotes the co-first author.
*denotes the corresponding author.

  1. Sun, H.Ӱԭ, Liang, Y.Ӱԭ, Thompson, M.P., Gianneschi, N.C., "Degradable Polymers via Olefin Metathesis Polymerization", Prog. Polym. Sci., 2021, 120, 101427.
  2. Scheutz, G.M., Elgoyhen, J., Bentz, K.C., Xia, Y., Sun, H., Zhao, J., Savin, D.A., Sumerlin, B.S., "Mediating Covalent Crosslinking of Single-Chain Nanoparticles through Solvophobicity in Organic Solvents", Polym. Chem., 2021, in press.
  3. Zhou, X., Gong, X., Cao, W., Forman, C.J., Oktawiec, J., DӰԭ Alba, L., Sun, H., Thompson, M.P., Hu, Z., Kapoor, U., McCallum, N.C., Malliakas, C.D., Farha, O.K., Jayaraman, A., Shawkey, M.D., Gianneschi, N.C., "Anisotropic Synthetic Allomelanin Materials via Solid State Polymerization of Self-Assembled 1,8-Dihydroxynaphthalene Dimers", Angew. Chem. Int. Ed., 2021. DOI: 10.1002/anie.202103447.
  4. Hu, Z., Sun, H., Thompson, M.P., Xiao, M., Allen, M.C., Zhou, X., Ni, Q., Wang, Z., Li, W., Burkart, M.D., Deheyn, D.D., Dhinojwala, A., Shawkey, M.D., Gianneschi, N.C. "Structurally Colored Inks from Synthetic Melanin-Based Crosslinked Supraparticles", ACS Materials Lett., 2021, 3, 50Ӱԭ55.
  5. Sun, H.Ӱԭ, Cao, W.Ӱԭ, Zang, N.Ӱԭ, Clemons, T. D., Scheutz, G. M., Hu, Z., Thompson, M. P., Liang, Y., Vratsanos, M., Zhou, X., Choi, W., Sumerlin, B. S., Stupp, S. I, Gianneschi, N. C. ӰԭProapoptotic Peptide Brush Polymer Nanoparticles via Photoinitiated Polymerization-Induced Self-Assembly.Ӱԭ Angew. Chemie. Int. Ed. 2020, 59, 43, 19136-19142.
  6. Choi, W.; Sun, H.; Battistella, C.; Berger, O.; Vratsanos, M.A.; Wang, M.; Gianneschi, N. C., ӰԭBiomolecular densely grafted brush polymers: oligonucleotides, oligosaccharides and oligopeptidesӰԭ, Angew. Chem. Int. Ed., 2020, 59, 45, 19762-19772.
  7. Zhu, J.; Sun, H.; Callmann, C. E.; Thompson, M. P.; Battistella, C.; Proetto, M. T.; Carlini, A.S.; Gianneschi, N. C., ӰԭPaclitaxel-terminated peptide brush polymersӰԭ, Chem. Commun., 2020, 56, 6778-6781.
  8. Liang, Y.; Sun, H.*; Cao, W.; Thompson, M. P.; Gianneschi, N. C.* "Degradable Polyphosphoramidate via Ring-Opening Metathesis Polymerization." ACS Macro Lett. 2020, 9, 10, 1417Ӱԭ1422.
  1. Noh, J.; Cao, W.; Sun, H.; Yang, Y.; Gianneschi, N. C.; Abbott, N., ӰԭSelf-Assembly of Macromolecules within Single Topological Defects of Nematic SolventsӰԭ, Chem. Mater., 2020, 32, 15, 6753Ӱԭ6764.
  2. Cao, W.; McCallum, N. C.; Ni, Q. Z.; Li W., Boyce, H.; Mao, H.; Zhou, X.; Sun, H.; Thompson, M. P.; Battistella, C.; Wasielewski, M. R.; Dhinojwala, A.; Shawkey, M. D.; Burkart, M. D.; Wang, Z.; Gianneschi, N. C., ӰԭSelenomelanin: An Abiotic Selenium Analogue of PheomelaninӰԭ, J. Am. Chem. Soc. 2020, 142, 29, 12802Ӱԭ12810.
  3. Cavell, A.; Krasecki, V.; Li, G.; Sharma, A.; Sun, H.; Thompson, M.P.; Forman, C.J.; Guo, S.; Hickman, R. J.; Parrish, K.; Aspuru-Guzik, A.; Cronin, L.; Gianneschi, N. C.; Goldsmith, R. H., ӰԭOptical monitoring of polymerizations in droplets with high temporal dynamic rangeӰԭ, Chem. Sci., 2020, 11, 2647-2656
  4. Dobbins, D. J.; Scheutz, G. M.; Sun, H.; Crouse, C.A.; Sumerlin, B. S., ӰԭGlass Transition Temperature Governs the Thermal Decrosslinking Behavior of Diels-Alder Crosslinked Polymethacrylate NetworksӰԭ, J. Polym. Sci., 2020, 58, 193-203.
  5. Sun, H.; Choi, W.; Zang, N.; Battistella, C.; Thompson, M. P.; Cao, W.; Zhou, X.; Forman, C.; Gianneschi, N. C., ӰԭBioactive Peptide Brush Polymers via Photoinduced Reversible-Deactivation Radical PolymerizationӰԭ, Angew. Chem. Int. Ed., 2019, 58, 17359-17364 (Selected for Back cover).
  6. Sun, H.; Yang, L; Thompson, M. P; Schara, S; Cao, W; Choi, W; Hu, Z; Zang, N; Tan, W; Gianneschi, N. C., ӰԭRecent Advances in Amphiphilic Polymer-Oligonucleotide Nanomaterials via Living/Controlled Polymerization TechnologiesӰԭ, Bioconjug. Chem., 2019, 30, 7, 1889-1904.
  7. Liu, D.; Zeng, R.; Sun, H.; Zhang, L.; Tan, J., ӰԭBlue Light-Initiated Alcoholic RAFT Dispersion Polymerization of Benzyl Methacrylate: A Detailed StudyӰԭ, Polymers, 2019, 11(8), 1284.
  8. Touve, M. A.; Wright, D. B.; Mu, C.; Sun, H.; Park, C.; Gianneschi, N. C., ӰԭBlock Copolymer Amphiphile Phase Diagrams by High-Throughput Transmission Electron MicroscopyӰԭ, Macromolecules, 2019, 52, 5529-5537.
  9. Fuller, E.G. Ӱԭ; Sun, H. Ӱԭ; Dhavalikar, R.D.; Unni, M.; Scheutz, G. M.; Sumerlin, B. S.; Rinaldi, C., ӰԭExternally Triggered Heat and Drug Release from Magnetically Controlled NanocarriersӰԭ, ACS Applied Polymer Materials, 2019, 1, 211-220. (EditorӰԭs top pick)
  10. Sun, H.; Kabb, C. P.; Sims, M. B.; Sumerlin, B. S., ӰԭArchitecture-Transformable Polymers: Reshaping the Future of Stimuli-Responsive PolymersӰԭ, Prog. Polym. Sci., 2019, 89, 61-75. (ESI highly cited paper)
  11. Tan, J.; Dai, X.; Zhang, Y.; Yu, L.; Sun, H.; Zhang, L., ӰԭPhotoinitiated polymerization-induced self-assembly via visible light-induced RAFT-mediated emulsion polymerizationӰԭ, ACS Macro Lett, 2019, 8, 205-212. (Selected for cover; ESI highly cited paper).
  12. Yang, L.; Sun, H.; Liu, Y.; Hou, W.; Yang, Y.; Cai, R.; Cui, C.; Zhang, P.; Pan, X.; Li, X.; Li, L.; Sumerlin, B. S.; Tan, W., ӰԭSelf-Assembled Aptamer-Hyperbranched Polymer Nanocarrier for Targeted and Photoresponsive Drug DeliveryӰԭ, Angew. Chem. Int. Ed., 2018, 57, 17048-17052.
  13. Tang, H.; Luan, Y.; Yang, L.; Sun, H.*, ӰԭA Perspective on Reversibility in Controlled Polymerization Systems: Recent Progress and New OpportunitiesӰԭ, Molecules, 2018, 23(11), 2870. (Corresponding author).
  14. Liu, Y.; Sun, H.; Yang, L.; Liang, J.; Li, X.; Jiang, Y.; Hou, W.; Ferreira, C.; Talham, D. R.; Tan, W., ӰԭChelation-Assisted Assembly of Multidentate Colloidal Nanoparticles into Metal-Organic NanoparticlesӰԭ, Nanoscale, 2018, 10, 21369-21373.
  15. Yang, L.; Tang, H.; Sun, H.*, ӰԭProgress in Photo-Responsive Polypeptide Derived Nano-AssembliesӰԭ, Micromachines, 2018, 9, 296. (Corresponding author).
  16. Li, X.; Figg, A.; Wang, R.; Jiang, Y.; Lyu, Y.; Sun, H.; Liu, Y.; Wang, Y.; Hou, W.; Cai, R.; Cui, C.; Li, L.; Pan, X.; Sumerlin, B. S.; Tan, W., ӰԭCross-Linked Aptamer-Lipid Micelles for Excellent Stability and Specificity in Target Cell RecognitionӰԭ, Angew. Chem. Int. Ed., 2018, 57, 115899-11593.
  17. Sun, H.; Kabb, C. P.; Dai, Y.; Hill, M. R.; Ghiviriga, I.; Bapat, A. P.; Sumerlin, B. S., ӰԭMacromolecular Metamorphosis via Stimulus-Induced Transformations of Polymer ArchitectureӰԭ, Nature Chemistry, 2017, 9, 817-823. (Highlighted in Chemistry World 2017, February 21st).
  18. Dai, Y.; Sun, H.; Pal, S.; Zhang, Y.; Park, S.; Kabb, C. P.; Wei, W.; Sumerlin, B. S., ӰԭNear-IR-Induced Dissociation of Thermally-Sensitive Star PolymersӰԭ, Chem. Sci., 2017, 8, 1815-1821.
  19. Liu, Y.; Hou, W.; Sun, H.; Cui, C.; Zhang, L.; Jiang, Y.; Wu, Y.; Wang, Y.; Li, J.; Sumerlin, B. S.; Liu, Q.; Tan, W., ӰԭThiol-Ene Click Chemistry: A Biocompatible Way for Orthogonal Bioconjugation of Colloidal NanoparticlesӰԭ, Chem. Sci., 2017, 8, 6182-6187.
  20. Wan, S.; Zhang, L.; Wang, S.; Liu, Y.; Wu, C.; Cui, C.; Sun, H.; Shi, M.; Jiang, Y.; Li, L.; Qiu, L.; Tan, W., ӰԭMolecular Recognition-Based DNA Nanoassemblies on the Surfaces of Nanosized ExosomesӰԭ, J. Am. Chem. Soc., 2017, 139 (15), 5289-5292. (ESI highly cited paper).
  21. Alfurhood, J. A.; Sun, H.; Kabb, C. P.; Tucker, B. S.; Matthews, J. H.; Luesch, H.; Sumerlin, B. S., ӰԭPoly(N-(2-Hydroxypropyl) Methacrylamide)-Valproic Acid Conjugates as Block Copolymer NanocarriersӰԭ, Polym. Chem., 2017, 8, 4983-4987.
  22. Wang, Y.; Wu, C.; Chen, T.; Sun, H.; Cansiz, S.; Zhang, L.; Cui, C.; Hou, W.; Wu, Y.; Wan, S.; Cai, R.; Liu, Y.; Sumerlin, B. S.; Zhang, X.; Tan, W., ӰԭDNA Micelle Flares: A Study of the Basic Properties that Contribute to Enhanced Stability and Binding Affinity in Complex Biological SystemsӰԭ, Chem. Sci., 2016, 7, 6041-6049
  23. Dong, P.; Sun, H.; Quan, D., ӰԭSynthesis of Poly(L-lactide-co-5-amino-5-methyl-1,3-dioxan-2-ones)[P(L-LA-co-TAc)] Containing Amino Groups via Organocatalysis and Post-Polymerization FunctionalizationӰԭ, Polymer, 2016, 97, 614-622.
  24. Alfurhood, J.A.; Sun, H.; Bachler, P. R.; Sumerlin, B. S., ӰԭHyperbranched Poly(N-(2-Hydroxypropyl) Methacrylamide) via RAFT Self-Condensing Vinyl PolymerizationӰԭ, Polym. Chem., 2016, 7, 2099-2104.
  25. Sun, H.; Dobbins, D. J.; Dai, Y.; Kabb, C. P.; Wu, S.; Alfurhood, J. A.; Rinaldi, C.; Sumerlin, B. S., ӰԭRadical Departure: Thermally-Triggered Degradation of Azo-Containing Poly(β-Thioester)sӰԭ, ACS Macro lett, 2016, 5, 688-693.
  26. Tan, J.; Sun, H.; Yu, M.; Sumerlin, B. S.; Zhang, L., ӰԭPhoto-PISA: Shedding Light on Polymerization-Induced Self-AssemblyӰԭ, ACS Macro lett, 2015, 4, 1249-1253. (ESI highly cited paper)
  27. Sun, H.; Kabb, C.P.; Sumerlin, B. S., ӰԭThermally-Labile Segmented Hyperbranched Copolymers: Using Reversible-Covalent Chemistry to Investigate the Mechanism of Self-Condensing Vinyl CopolymerizationӰԭ, Chem. Sci., 2014, 5, 4646-4655.
Patents
  1. Rinaldi, C.; Sun, H.; Sumerlin, B. S., ӰԭMagnetic Particle Conjugates, Micelles, and Methods of Delivering AgentsӰԭ PCT/US17/028852, WO2017189356A1, 2019.
  2. Gianneschi, N.C.; Lavine, J.A.; Zhang, B.; Berger, O.; Choi, W.; Wang, M.; Battistella, C.; Sun, H., ӰԭBrush Polymers for Therapeutic ApplicationsӰԭ PCT/US2020/045729, WO/2021/030326, 2020.
  3. Gianneschi, N.C.; Sun, H., ӰԭBioactive Peptide Brush Polymers via Photoinduced Reversible-Deactivation Radical PolymerizationӰԭ PCT/US2020/053308, WO/2021/067293, 2020.
  4. Gianneschi, N.C.; Liang, Y.; Sun, H., ӰԭFully and Partially Backbone-Degradable Polymers via Low Temperature Ring-Opening Metathesis Polymerization (ROMP)Ӱԭ US Provisional 63/047,799, 2020.